PTC CLINIC
Information for Healthcare Professionals

Overview of published work and relevant studies of PTC experts for proton therapy of lymphomas:

1. Ntentas Georgios DPhil, Dedeckova Katerina MD, Andrlik Michal MSc, Aznar Marianne C. PhD, George Ben PhD, Kubes Jirí MD, PhD, C. Darby Sarah PhD,. Cutter David J FRCR, DPhil. Clinical Intensity Modulated Proton Therapy for Hodgkin Lymphoma: Which Patients Benefit the Most? Practical Radiation Oncology (2019) 9, 179-187.
2. Shbib Dabaja, B., Hoppe, B., Plastaras, J., Newhauser, W., Rosolova, K., Flamour, S., Mohan, R., Mikhaeel, G., Kirova, Y., Specht, L., Yahalom, J. (2018). Proton therapy for adults with mediastinal lymphomas: the international lymphoma radiation oncology group (ilrog) guidelines. Blood. Retrieved from http://www.bloodjournal.org/content/early/2018/08/14/blood-2018-03-837633.long?sso-checked=true.
3. Ntentas, G., Dědečková K., Andrilik, M., Aznar, M.C., George, B., Darby, S.C., Cutter, D. (2017). Predicted cardiac and second cancer risks in hodgkin lymphoma patients treated with advanced proton beam therapy compared to photon radiation therapy. S181 ASTRO Annual Metting. International Journal of Radiation Oncology, Biology, Physics, 99(2). doi: https://doi.org/10.1016/j.ijrobp.2017.06.454.
4. Yolanda D. Tseng, MD, David J. Cutter, MD, DPhil, FRCR, John P. Plastaras, MD, PhD, Rahul R. Parikh, MD, Oren Cahlon, MD, Michael D. Chuong, MD, Katerina Dedeckova, MD, Mohammad K. Khan, MD, PhD, Shinn-Yn Lin,MD, Lisa A. McGee, MD, Eric Yi-Liang Shen, MD, Stephanie A. Terezakis, MD, Shahed N. Badiyan, MD, Youlia M. Kirova, MD, Richard T. Hoppe,MD, Nancy P. Mendenhall, MD, Mark Pankuch, PhD, Stella Flampouri, PhD, Umberto Ricardi, MD, and Bradford S. Hoppe, MD, MPH. Evidence-based Review on the Use of Proton Therapy in Lymphoma From the Particle Therapy Cooperative Group (PTCOG) Lymphoma Subcommittee International Journal for Radiation Oncology, Biology, Physics. (2017) Nov 15; 99(4):825-842. doi: 10.1016/j.ijrobp.2017.05.004. Epub 2017 Sep 21.
5. Dedeckova, K., Stokucova J., Mocikova, H., Markova, J., Gaherova, L., Kantorova, I., Ondrova, B., Vondracek, V., Vitek, P., Kubes, J. (2016). Pencil beam scanning proton therapy for lymphoma patients with mediastinal involvement: Prague´s single institution experience. PTCOG Conference. Retrieved from https://www.czech-in.org/cm/PTCOG/CM.NET.WebUI/CM.NET.WEBUI.scpr4/SCPRfunctiondetail.aspx?confID=05000000-0000-0000-0000-000000000066&sesID=05000000-0000-0000-0000-000000004711&absID=07000000-0000-0000-0000-000000036887
6. Dedeckova K., Markova J., Gaherova, L., Kantorova, I., Ondrova, B., Vondracek, V., Vitek, P., Kubes, J. (2016). Proton radiotherapy for mediastinal Hodgkin lymphoma: single institution experience. 10th International Symposium on Hodgkin Lymphoma. Retrieved from https://www.hodgkinsymposium.org/media/469-f203b911.
7. Dedeckova, K., Mocikova, H., Markova, J., Gaherova, L., Koren, J., Backova, B., Vondracek, V., Sindelar, D., Kohlova, T., Ondrova, B., Kantorova, I., Vitek, P., Pytlik, R., Kubes, J. (2015). Pencil Beam Scanning Proton Therapy for Lymphoma Patients with Mediastinal Involvement: A Dosimetric Study and Preliminary Clinical Data. Hematological Oncology, 33, 191. Retrieved from http://www.lymphcon.ch/icml/website/doc/ICML_AbstractBooks_vecchi/13-ICMLJune%2017-202015/13-ICML_AB_Poster.pdf.
8. Kubeš, J., Vítek, P., Dědečková, K., Ondrová, B. (2014). Velmi pozdní následky radioterapie – limitující faktor současných radioterapeutických Technik (Very late side effects of radiotherapy – limiting factor of current radiotherapeutic techniques). Klinicka onkologie Journal, 27(3), 161-165. doi: 14735/amko2014161.
9. Dědečková K, Móciková H, Belada D, Janíková A, Dolečková M, Malinová B, Feltl D, Vošmik M, Svoboda T, Marková J, Trněný M. (2013). The role of radiotherapy in the treatment of malignant lymphomas – recommendations of the Czech Lymphoma Study Group. Klinicka onkologie Journal, 26(2), 99-109. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/23718668. PubMed PMID: 23718668.
10. Dědečková, K., Móciková, H., Belada, D., Obořilová-Janíková, A., Dolečková, M., Malinová, B., Feltl, D., Vošmik, M., Svoboda, T., Marková, J., Trněný, M.(2013). Postavení radioterapie v léčbě maligních lymfomů – doporučení Kooperativní lymfomové skupiny (The Position of radiotherapy in the treatment of malignant lymphomas – recommendations of the cooperative lymphoma group). Klinicka onkologie Journal, 26(2), 99-109. doi: 14735/amko201399.
11. Marková J., Kahraman D., Kobe C., Skopalová M., Móciková H., Klásková K., Dědečková, , Eich H.T., Böll B., Dietlein M., Kozák T. (2012). Role of (18F)-fluoro-2-deoxy-D-glucose positron emission tomography in early and late therapy assessment of patients with advanced Hodgkin lymphoma treated with bleomycin, etoposide, Adriamycin, cyclophosphamide, vincristine, procarbazine and prednisone. Leukemia & Lymphoma, 53(1), 64-70. doi: 10.3109/10428194.2011.603444.
12. Chocenská, E., Móciková, H., Dědečková K. (2010). Průvodce pacienta onkologickou léčbou (Patient’s Guide to Cancer Treatment). Retrieved from https://www.linkos.cz/pacient-a-rodina/pomoc-v-nemoci/kde-hledat-informace/onkologicke-knihy/pruvodce-pacienta-onkologickou-lecbou/.
13. Marková J., Kobe C., Skopalová M., Klásková K., Dědečková, Plütschow A., Eich H.T., Dietlein M., Engert A., Kozák T. (2009). FDG-PET for assessment of early treatment response after four cycles of chemotherapy in patients with advanced-stage Hodgkin’s lymphoma has a high negative predictive value. Annals of Oncology, (20)7. 1270-4. doi: 10.1093/annonc/mdn768.
14. Marková, J., Kobe C., Skopalová, M., Žikavská, L., Vernerová, Z., Klásková, K., Dědečková, K., Eich, H.T., Dietlein, M., Fuchs, M., Engert, A., Kozák, T. (2009). Early and late response assessment with fdg-pet after beacopp-based chemotherapy in advanced-stage Hodgkin lymphoma patients has a high negative predictive value. Haematologica, 94(2). Retrieved from http://online.haematologica.org/EHA14/browserecord.php?-action=browse&-recid=3189
15. Tseng YD, Hoppe BS, Dedeckova K, Patel CG, Hill-Kayser CE, Miller DM, Maity A, Mendenhall NP, Mailhot Vega RB, Yock TI, Baliga S, Hess CB, Winkfield KM, Mohindra P, Rosen LR, Tsai H, Chang J, Hartsell WF, Plastaras JP. Risk of Pneumonitis and Outcomes After Mediastinal Proton Therapy for Relepsed/Refractory Lymphoma: A PTCOG and PCG Collaboration. Int J Radiat Oncol Biol Phys. 2021 Jan 1;109(1): 220-230. doi: https://doi.org/10.1016/j.ijrobp.2020.08.055

Map of complex oncological and hematooncological centers:

https://www.linkos.cz/pacient-a-rodina/lecba/kde-se-lecit/onkologicka-pracoviste/#search=1

Domestic sources of information (Czech Republic):

www.hodgkin.cz professional public and patients, comprehensive information on Hodgkin’s lymphoma for doctors and patients, brochures and counseling for patients.

www.lymphoma.cz professional public and patients, comprehensive information on the issues of Hodgkin’s and non-Hodgkin’s lymphoma, available current recommendations for the diagnosis and treatment of lymphomas, including RT.

www.lymfomhelp.cz patients, comprehensive information and assistance for patients before, during or after lymphoma treatment.

www.linkos.cz professional public and patients, website of the Czech Oncological Society.

www.srobf.cz professional public, website of the Society of Radiation Oncology, Biology and Physics.

https://www.amelie-zs.cz/ psychosocial assistance project for patients with cancer.

Foreign sources of information:

www.nccn.org professional public and patients, guidelines for individual types of cancer, including recommended irradiation techniques.

https://www.ptcog.ch/index.php/other-ptcog-sub-committees?id=53 professional public, information on publications related to proton RT for lymphomas.

www.ilrog.com professional public, information on the status and implementation of radiotherapy in lymphomas.

www.ihaddcancer.com self-help project and sharing the experiences of patients who have been or are being treated for cancer.

Videos about proton therapy for lymphoma (in English):

https://www.youtube.com/watch?v=prh-5CQ3nsY, dr. Gomez, Proton Therapy Treatment for Lymphoma, MD Anderson Proton Therapy Center.

https://www.youtube.com/watch?v=NNLoQSaAuzA , dr.Hoppe, Proton Therapy for Lymphoma, University of Florida Proton Therapy Institute.

https://www.youtube.com/watch?v=VlKlPuKrSSw, dr.Dabaja, Proton and photon therapy in managing hematological malignancies, MD Anderson Cancer Center, Houston, TX.