Jsme akreditované zařízení pro magnetickou rezonanci v rámci pilotního programu screeningu karcinomu prostaty.

 

Reference

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  21. König, L., Haering, P., Lang, C., Splinter, M., von Nettelbladt, B., Weykamp, F., Hoegen, P., Lischalk, J. W., Herfarth, K., Debus, J., Hörner-Rieber, J.. Secondary Malignancy Risk Following Proton vs. X-ray Treatment of Mediastinal Malignant Lymphoma: A Comparative Modeling Study of Thoracic Organ-Specific Cancer Risk. Front Oncol. 2020, 10, 989. doi: 10.3389/fonc.2020.00989
  22. Loap P, Mirandola A, De Marzi L, Dendale R, Iannalfi A, Vitolo V, Barcellini A, Filippi AR, Jereczek-Fossa BA, Kirova Y, Orlandi E. Current Situation of Proton Therapy for Hodgkin Lymphoma: From Expectations to Evidence. Cancers (Basel). 2021 Jul 26;13(15):3746. doi: 10.3390/cancers13153746. PMID: 34359647; PMCID: PMC8345146.
  23. Loap P, De Marzi L, Mirandola A, Dendale R, Iannalfi A, Vitolo V, Barcellini A, Filippi AR, Jereczek-Fossa BA, Kirova Y, Orlandi E. Development and Implementation of Proton Therapy for Hodgkin Lymphoma: Challenges and Perspectives.Cancers (Basel). 2021 Jul 26;13(15):3744. doi: 10.3390/cancers13153744. PMID: 34359644; PMCID: PMC8345082.
  24. Tringale KR, Modlin LA, Sine K, Forlenza CJ, Cahlon O, Wolden SL. Vital organ sparing with proton therapy for pediatric Hodgkin lymphoma: Toxicity and outcomes in 50 patients.Radiother Oncol. 2022 Mar;168:46-52. doi: 10.1016/j.radonc.2022.01.016. Epub 2022 Jan 29. PMID: 35101461; PMCID: PMC9446376
  25. Patel CG, Peterson J, Aznar M, Tseng YD, Lester S, Pafundi D, Flampouri S, Mohindra P, Parikh RR, Mailhot Vega R, Konig L, Plastaras JP, Bates JE, Loap P, Kirova YM, Orlandi E, Lütgendorf-Caucig C, Ntentas G, Hoppe B. Systematic review for deep inspiration breath hold in proton therapy for mediastinal lymphoma: A PTCOG Lymphoma Subcommittee report and recommendations. Radiother Oncol. 2022 Dec;177:21-32. doi: 10.1016/j.radonc.2022.10.003. Epub 2022 Oct 14. PMID: 36252635.
  26. Tseng YD, Pankuch M, Mohindra P, McGee L, Rossi C, Flampouri S, Hajj C, Molitoris JK, Chang JH, Tsai H, Stevens C, Rosen L, Vargas C, Hartsell W. Selection of Mediastinal Lymphoma Patients for Proton Therapy Within the Proton Collaborative Group Registry: Concordance With the ILROG Guidelines. Am J Clin Oncol. 2021 Jun 1;44(6):269-274. doi: 10.1097/COC.0000000000000819. PMID: 33852456.
  27. Loap P, Orlandi E, De Marzi L, Vitolo V, Barcellini A, Iannalfi A, Dendale R, Kirova Y, Mirandola A. Cardiotoxicity model-based patient selection for Hodgkin lymphoma proton therapy. Acta Oncol. 2022 Aug;61(8):979-986. doi: 10.1080/0284186X.2022.2084639. Epub 2022 Jun 6. PMID: 35668710.
  28. Buglione M, Guerini AE, Filippi AR, Spiazzi L, Pasinetti N, Magli A, Toraci C, Borghetti P, Triggiani L, Alghisi A, Costantino G, Bertagna F, Giaj Levra N, Pegurri L, Magrini SM. A Systematic Review on Intensity Modulated Radiation Therapy for Mediastinal Hodgkin’s Lymphoma. Crit Rev Oncol Hematol. 2021 Nov;167:103437. doi: 10.1016/j.critrevonc.2021.103437. Epub 2021 Aug 3. PMID: 34358649.
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Reference CAR-T

  1. Van Den Neste E, Schmitz N, Mounier N, Gill D, Linch D, Trneny M, Milpied N, Radford J, Ketterer N, Shpilberg O, Dührsen U, Ma D, Brière J, Thieblemont C, Salles G, Moskowitz CH, Glass B, Gisselbrecht C. Outcome of patients with relapsed diffuse large B-cell lymphoma who fail second-line salvage regimens in the International CORAL study. Bone Marrow Transplant. 2016 Jan;51(1):51-7. doi: 10.1038/bmt.2015.213. Epub 2015 Sep 14. PMID: 26367239.
  2. Crump M, Neelapu SS, Farooq U, Van Den Neste E, Kuruvilla J, Westin J, Link BK, Hay A, Cerhan JR, Zhu L, Boussetta S, Feng L, Maurer MJ, Navale L, Wiezorek J, Go WY, Gisselbrecht C. Outcomes in refractory diffuse large B-cell lymphoma: results from the international SCHOLAR-1 study. 2017 Oct 19;130(16):1800-1808. doi: 10.1182/blood-2017-03-769620. Epub 2017 Aug 3. Erratum in: Blood. 2018 Feb 1;131(5):587-588. doi: 10.1182/blood-2017-11-817775. PMID: 28774879; PMCID: PMC5649550.)
  3. Jain MD, Spiegel JY, Nastoupil LJ, Tamaresis J, Ghobadi A, Lin Y, Lekakis L, Reagan P, Oluwole O, McGuirk J, Deol A, Dorritie KA, Sehgal AR, Goy A, Hill BT, Andreadis C, Munoz J, Ulrickson M, Westin J, Chavez JC, Patel D, Jacobs MT, Bansal R, Bennani NN, Patel VG, Rapoport AP, Vose JM, Miklos DB, Neelapu SS, Locke FL, Lunning M, Dahiya S. Five-Year Follow-Up of Standard-of-Care Axicabtagene Ciloleucel for Large B-Cell Lymphoma: Results From the US Lymphoma CAR T Consortium. J Clin Oncol. 2024 Oct 20;42(30):3581-3592. doi: 10.1200/JCO.23.02786. Epub 2024 Aug 2. PMID: 39094076; PMCID: PMC11483191.) Jain MD, Spiegel JY, Nastoupil LJ, Tamaresis J, Ghobadi A, Lin Y, Lekakis L, Reagan P, Oluwole O, McGuirk J, Deol A, Dorritie KA, Sehgal AR, Goy A, Hill BT, Andreadis C, Munoz J, Ulrickson M, Westin J, Chavez JC, Patel D, Jacobs MT, Bansal R, Bennani NN, Patel VG, Rapoport AP, Vose JM, Miklos DB, Neelapu SS, Locke FL, Lunning M, Dahiya S. Five-Year Follow-Up of Standard-of-Care Axicabtagene Ciloleucel for Large B-Cell Lymphoma: Results From the US Lymphoma CAR T Consortium. J Clin Oncol. 2024 Oct 20;42(30):3581-3592. doi: 10.1200/JCO.23.02786. Epub 2024 Aug 2. PMID: 39094076; PMCID: PMC11483191.)
  4. Pinnix CC, Gunther JR, Dabaja BS, Strati P, Fang P, Hawkins MC, Adkins S, Westin J, Ahmed S, Fayad L, Lee HJ, Nair R, Steiner RE, Iyer SP, Rodriguez MA, Wang M, Flowers C, Neelapu SS, Nastoupil LJ. Bridging therapy prior to axicabtagene ciloleucel for relapsed/refractory large B-cell lymphoma. Blood Adv. 2020 Jul 14;4(13):2871-2883. doi: 10.1182/bloodadvances.2020001837. PMID: 32589728; PMCID: PMC7362355.)
  5. Fan J, Adams A, Sieg N, Heger JM, Gödel P, Kutsch N, Kaul D, Teichert M, von Tresckow B, Bücklein V, Goesmann G, Li M, Struve N, Trommer M, Linde P, Rosenbrock J, Celik E, Penack O, Stuschke M, Subklewe M, Belka C, von Bergwelt-Baildon M, Borchmann P, Marnitz S, Baues C. Potential synergy between radiotherapy and CAR T-cells – a multicentric analysis of the role of radiotherapy in the combination of CAR T cell therapy. Radiother Oncol. 2023 Jun;183:109580. doi: 10.1016/j.radonc.2023.109580. Epub 2023 Feb 25. PMID: 36842663.
  6. Guerini AE, Filippi AR, Tucci A, Simontacchi G, Re A, Guaineri A, Morelli V, Borghetti P, Triggiani L, Pegurri L, Pedretti S, Volpi G, Spiazzi L, Magrini SM, Buglione M. ‚Le Roi est mort, vive le Roi‘: New Roles of Radiotherapy in the Treatment of Lymphomas in Combination With Immunotherapy. Clin Lymphoma Myeloma Leuk. 2022 Feb;22(2):e135-e148. doi: 10.1016/j.clml.2021.09.005. Epub 2021 Sep 10. PMID: 34728169
  7. Manzar GS, Wu SY, Dudzinski SO, Cha EE, Yoder AK, Corrigan KL, Nasr LF, Sallard G, Ahmed S, Fayad LE, Chihara D, Nair R, Westin JR, Daher M, Neelapu SS, Nastoupil LJ, Gunther JR, Pinnix CC, Dabaja BS, Strati P, Fang PQ. Characterization of Lymphopenia and Correlating the Risk of Cytopenias With Dose and Bone Marrow Volume Irradiated in Aggressive B Cell Lymphoma Patients Bridged With Radiation Therapy for Chimeric Antigen Receptor-T Cell Therapy. Int J Radiat Oncol Biol Phys. 2024 Sep 19:S0360-3016(24)03394-7. doi: 10.1016/j.ijrobp.2024.09.023. Epub ahead of print. PMID: 39303997.
  8. de Boer JW, Pennings ERA, Kleinjan A, van Doesum JA, Spanjaart AM, Mutsaers PGNJ, Jak M, van der Poel MWM, Kuipers MT, Adam JA, Diepstra A, Koens L, van Dorp S, Vermaat JSP, Niezink AGH, Kersten MJ, van Meerten T. Inflammatory reactions mimic residual or recurrent lymphoma on [18F]FDG-PET/CT after CD19-directed CAR T-cell therapy. Blood Adv. 2023 Nov 14;7(21):6710-6716. doi: 10.1182/bloodadvances.2023010665. PMID: 37639324; PMCID: PMC10641469.

Klinické studie – účast PTC

  1. IESLG 37 – Role konsolidační RT u pacientů s primárním mediastinálním B-lymfomem. Interní hematologická klinika FN Královské Vinohrady, Onkologická klinika 2. LF UK a Fakultní nemocnice Motol (zajištění moderní fotonové RT – technika IMRT, VMAT)
  2. Dose – Reduced Consolidation Radiation Therapy in Patients With Diffuse Large B-cell Lymphoma – Fáze II studie Konsolidační radioterapie s redukcí dávky u pacientů  s difuzním velkobuněčným B- lymfomem. Mezinárodní studie DLBCL – ILROG Paris Research Collaboration – Phase II DLBCL Study vedena DUKE Cancer Institute, Department of Radiology. Účast společně s FN Motol.
  3. Impact of DHL/THL on RT efficacy for r/r DLBCL patients – ILROG collaborative study. Účast ve studii ILROG s DHL/THL DLBCL, studii vede University of Washington, Dr. Yolanda Tseng.
  4. An Excess Mortality Risk Analysis of Proton Beam versus Optimal Proton Radiotherapy for Mediastinal Hodgkin  Lymphoma: Who May Benefit Most? – Modelová studie s Nuffield Dpt. University of Oxford + St. Guy´s Hospital – pokračující spolupráce, analýza souboru pacientů PTC.
  5. EuroNet – PHL – C2 – ve spolupráci s FN Motol, studie vedena Prof. Karin Dieckmann, AKH Wien.

Tuzemské zdroje informací

  1. www.hodgkin.cz  odborná veřejnost i pacienti, komplexní informace o Hodgkinově lymfomu pro lékaře i pacienty, brožura a poradna pro pacienty.
  2. www.lymphoma.cz odborná veřejnost i pacienti, komplexní informace týkající se problematiky Hodgkinova I non-Hodgkinova lymfomu, k dispozici aktuální doporučení pro diagnostiku a léčbu lymfomů včetně RT.
  3. www.lymfomhelp.cz pacienti, komplexní informace a pomoc pro pacienty před, v léčbě či po léčbě lymfomu.
  4. www.linkos.cz odborná veřejnost i pacienti, stránky České onkologické společnosti.
  5. www.srobf.cz  odborná veřejnost, stránky Společnosti radiační onkologie, biologie a fyziky.
  6. https://www.amelie-zs.cz/ Projekt psychosociální pomoci, pro pacienty s nádorovým onemocněním.

Zahraniční zdroje informací

  1. www.nccn.org odborná veřejnost i pacienti, doporučení (guidelines) pro jednotlivé typy zhoubných nádorů včetně doporučených technik ozáření.
  2. https://www.ptcog.ch/index.php/other-ptcog-sub-committees?id=53  odborná veřejnost, informace o publikacích týkající se protonové RT lymfomů.
  3. www.ilrog.com odborná veřejnost, informace o postavení a provedení radioterapie u lymfomů.
  4. www.ihaddcancer.com projekt svépomoci a sdílení zkušeností pacientů, kteří se léčili nebo léčí s rakovinou.

Videa k protonové RT lymfomů (anglicky)

  1. https://www.youtube.com/watch?v=prh-5CQ3nsY, dr. Gomez, Proton Therapy Treatment for Lymphoma, MD Anderson Proton Therapy Center.
  2. https://www.youtube.com/watch?v=NNLoQSaAuzA , dr.Hoppe, Proton Therapy for Lymphoma, University of Florida Proton Therapy Institute.
  3. https://www.youtube.com/watch?v=VlKlPuKrSSw, dr.Dabaja, Proton and photon therapy in managing hematological malignancies, MD Anderson Cancer Center, Houston, TX

 

Kniha Protonová radioterapie, autor Pavel Vítek a kol., vydalo nakl. Maxdorf

Kniha k zakoupení prostřednictvím odkazu níže.